Version 5.4
| Bos taurus Gene: TYMS | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-644129.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | TYMS | ||||||||||
| Gene Name | thymidylate synthase | ||||||||||
| Synonyms | TS | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000007003 | ||||||||||
| Encoded Proteins |
thymidylate synthase
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176890:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 24:35935176-35945792 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Pyrimidine biosynthesis pathway
Metabolism of nucleotides pathway
Mitotic G1-G1/S phases pathway
G1/S Transition pathway
Cell Cycle pathway
Pyrimidine metabolism pathway
Cell Cycle, Mitotic pathway
Metabolism pathway
Pyrimidine biosynthesis pathway
Cell Cycle, Mitotic pathway
Pyrimidine metabolism pathway
Cell Cycle pathway
Metabolism pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Metabolism of nucleotides pathway
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| KEGG |
Pyrimidine metabolism pathway
One carbon pool by folate pathway
Pyrimidine metabolism pathway
One carbon pool by folate pathway
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| INOH |
Folate metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
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| PID NCI |
E2F transcription factor network
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | Bt.7738 | ||||||||||
| RefSeq | NM_001037816 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||