Homo sapiens Gene: PCNT
Summary
InnateDB Gene IDBG-6445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCNT
Gene Name pericentrin
Synonyms KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2; SCKL4;
Species Homo sapiens
Ensembl Gene ENSG00000160299
Encoded Proteins
pericentrin
pericentrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:46324122-46445769
Strand Forward strand
Band q22.3
Transcripts
ENST00000359568 ENSP00000352572
ENST00000418394 ENSP00000404708
ENST00000490468
ENST00000480896
ENST00000466474
ENST00000483844
ENST00000482575
ENST00000465356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0007051 spindle organization
GO:0021696 cerebellar cortex morphogenesis
GO:0021772 olfactory bulb development
GO:0035108 limb morphogenesis
GO:0035264 multicellular organism growth
GO:0042384 cilium assembly
GO:0043066 negative regulation of apoptotic process
GO:0048854 brain morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0090316 positive regulation of intracellular protein transport
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016020 membrane
GO:0031514 motile cilium
GO:0034451 centriolar satellite
GO:0036064 ciliary basal body
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5116
UniGene Hs.474069 Hs.614372
RefSeq NM_006031
HUGO HGNC:16068
OMIM 605925
CCDS CCDS33592
HPRD 05804
IMGT
EMBL
GenPept
RNA Seq Atlas 5116