InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PCNT

Summary

InnateDB Gene

IDBG-6445.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCNT

Gene Name

pericentrin

Synonyms

KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2; SCKL4

Species

Homo sapiens

Ensembl Gene

ENSG00000160299

Encoded Proteins

IDBP-6447

pericentrin

IDBP-371825

pericentrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:46324122-46445769

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000359568	ENSP00000352572
ENST00000418394	ENSP00000404708
ENST00000490468
ENST00000480896
ENST00000466474
ENST00000483844
ENST00000482575
ENST00000465356

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0007051	spindle organization
GO:0021696	cerebellar cortex morphogenesis
GO:0021772	olfactory bulb development
GO:0035108	limb morphogenesis
GO:0035264	multicellular organism growth
GO:0042384	cilium assembly
GO:0043066	negative regulation of apoptotic process
GO:0048854	brain morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0031514	motile cilium
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0045171	intercellular bridge