Version 5.4
Bos taurus Gene: COPS5
Summary
InnateDB Gene IDBG-644657.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS5
Gene Name COP9 signalosome complex subunit 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002784
Encoded Proteins
IDBP-697310
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21403132
[Homo sapiens] COPS5 is required for the activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of NFE2L2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis. (Demonstrated in murine model)
PMID 21403132
[Mus musculus] Cops5 is required for activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of Nfe2l2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121022:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:33207508-33226917
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003609 ENSBTAP00000003609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 636 interaction(s) predicted by orthology.
Predicted by orthology
Total 636 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
Biological Process
GO:0000338 protein deneddylation
GO:0010388 cullin deneddylation
GO:0016579 protein deubiquitination
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046328 regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:1990182 exosomal secretion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000121022
View Gene Order
ENSMUSG00000025917
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
ap1_pathway
AP-1 transcription factor network
hif1_tfpathway
HIF-1-alpha transcription factor network
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt
TrEMBL F1MBP8
UniProt Splice Variant
Entrez Gene 785657
UniGene
RefSeq NM_001192139 XM_001249855
HUGO HGNC:2240
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02038695
GenPept
RNA Seq Atlas 507179 785657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca