InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cops5

Summary

InnateDB Gene

IDBG-133028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cops5

Gene Name

COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)

Synonyms

AI303502; CSN5; Jab1; Mov34; Sgn5;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025917

Encoded Proteins

IDBP-133030

COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)

IDBP-789367

COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)

IDBP-789368

COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)

IDBP-789369

COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21403132

Cops5 is required for activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of Nfe2l2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis.

InnateDB Annotation from Orthologs

Summary

PMID 21403132

[Homo sapiens] COPS5 is required for the activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of NFE2L2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121022:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:10024601-10038168

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027050	ENSMUSP00000027050
ENSMUST00000139578
ENSMUST00000150509
ENSMUST00000190155	ENSMUSP00000140054
ENSMUST00000186528	ENSMUSP00000140633
ENSMUST00000188619	ENSMUSP00000140115
ENSMUST00000191296

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 668 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	668 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0000338	protein deneddylation
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0010388	cullin deneddylation
GO:0016579	protein deubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046328	regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1990182	exosomal secretion

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0008180	COP9 signalosome
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSG00000121022

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000002784

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID BIOCARTA

100145

Hypoxia-inducible factor in the cardivascular system [Biocarta view]

100176

Erythropoietin mediated neuroprotection through nf-kb [Biocarta view]

PID NCI

ap1_pathway

AP-1 transcription factor network

hif1_tfpathway

HIF-1-alpha transcription factor network

hif1apathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Cross-References

SwissProt

O35864

TrEMBL

Q3V0K7

UniProt Splice Variant

Entrez Gene

26754

UniGene

Mm.402384 Mm.474110

RefSeq

NM_013715

OMIM

CCDS

CCDS14818

HPRD

IMGT

MGI ID

MGI:1349415

MGI Symbol

Cops5

EMBL

AF065386 AF068223 AK012499 AK133073 AK146271 AK151492 BC046753 U70736

GenPept

AAC17179 AAD03470 AAF61318 AAH46753 BAB28282 BAE21497 BAE27030 BAE30445

RNA Seq Atlas

26754