Mus musculus Gene: Cops5
Summary
InnateDB Gene IDBG-133028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops5
Gene Name COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
Synonyms AI303502; CSN5; Jab1; Mov34; Sgn5;
Species Mus musculus
Ensembl Gene ENSMUSG00000025917
Encoded Proteins
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Cops5 is required for activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of Nfe2l2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] COPS5 is required for the activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of NFE2L2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121022:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10024601-10038168
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000027050 ENSMUSP00000027050
ENSMUST00000139578
ENSMUST00000150509
ENSMUST00000190155 ENSMUSP00000140054
ENSMUST00000186528 ENSMUSP00000140633
ENSMUST00000188619 ENSMUSP00000140115
ENSMUST00000191296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 668 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 668 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0000338 protein deneddylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis
GO:0010388 cullin deneddylation
GO:0016579 protein deubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046328 regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:1990182 exosomal secretion
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Erythropoietin mediated neuroprotection through nf-kb [Biocarta view]
PID NCI
AP-1 transcription factor network
HIF-1-alpha transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt O35864
TrEMBL Q3V0K7
UniProt Splice Variant
Entrez Gene 26754
UniGene Mm.402384 Mm.474110
RefSeq NM_013715
OMIM
CCDS CCDS14818
HPRD
IMGT
MGI ID MGI:1349415
MGI Symbol Cops5
EMBL AF065386 AF068223 AK012499 AK133073 AK146271 AK151492 BC046753 U70736
GenPept AAC17179 AAD03470 AAF61318 AAH46753 BAB28282 BAE21497 BAE27030 BAE30445
RNA Seq Atlas 26754