Version 5.4
| Bos taurus Gene: MD2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-644789.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | MD2 | ||||||||
| Gene Name | lymphocyte antigen 96 precursor | ||||||||
| Synonyms | ly-96; MD-2; MD2 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000008864 | ||||||||
| Encoded Proteins |
lymphocyte antigen 96
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] LY96 (MD-2) recognizes only exogenous pathogen-associated molecular patterns (PAMPs) when complexed with TLR2-CD14 or TLR4-CD14.
[Homo sapiens] LY86 and CD180 interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligand.
[Homo sapiens] LY96 is physically associated with TLR4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS).
[Homo sapiens] TLR4::LY96 functions as intracellular LPS sensor and triggers a unique set of LPS responses upon recognition of phagocytosed bacteria in macrophages. (Demonstrated in murine model)
[Homo sapiens] Amino acid Phe126 of LY96 acts as a hydrophobic switch driving agonist-dependent contacts necessary for TLR4 dimerization and activation.
[Homo sapiens] Morphine binds to LY96, triggering TLR4 oligomerization and induces neuroinflammation within the central nervous system.
[Mus musculus] Tlr4::Ly96 functions as intracellular LPS sensor and triggers a unique set of LPS responses upon recognition of phagocytosed bacteria in macrophages.
[Mus musculus] Amino acid Phe126 of Ly96 acts as a hydrophobic switch driving agonist-dependent contacts necessary for Tlr4 dimerization and activation. (Demonstrated in human)
[Mus musculus] Morphine binds to Ly96, triggering Tlr4 oligomerization and induces neuroinflammation within the central nervous system. (Demonstrated in human)
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154589:
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 14:39369425-39402263 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
TRAF6 mediated induction of TAK1 complex pathway
IKK complex recruitment mediated by RIP1 pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRIF-mediated programmed cell death pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
TRAF6 mediated induction of TAK1 complex pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll-Like Receptors Cascades pathway
TRIF-mediated programmed cell death pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Pathogenic Escherichia coli infection pathway
Toll-like receptor signaling pathway pathway
Toxoplasmosis pathway
Toll-like receptor signaling pathway pathway
Toxoplasmosis pathway
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| INOH |
Toll-like receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
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| PID NCI |
Endogenous TLR signaling
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | |||||||||
| RefSeq | NM_001046517 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||