Bos taurus Gene: FOXP1
Summary
InnateDB Gene IDBG-644975.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXP1
Gene Name Forkhead box protein P1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016533
Encoded Proteins
Forkhead box protein P1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114861:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30411677-30803681
Strand Forward strand
Band
Transcripts
ENSBTAT00000021993 ENSBTAP00000021993
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002329 pre-B cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0030324 lung development
GO:0033152 immunoglobulin V(D)J recombination
GO:0045214 sarcomere organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055007 cardiac muscle cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061140 lung secretory cell differentiation
GO:0072358 cardiovascular system development
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt A4IFD2
TrEMBL
UniProt Splice Variant
Entrez Gene 515903
UniGene Bt.17953
RefSeq NM_001083689 XM_005222651 XM_005222652 XM_005222653 XM_005222654 XM_005222655 XM_005222656 XM_005222657 XM_005222658
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134525
GenPept AAI34526
RNA Seq Atlas 515903
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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