InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FOXP1

Summary

InnateDB Gene

IDBG-644975.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXP1

Gene Name

Forkhead box protein P1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016533

Encoded Proteins

IDBP-697653

Forkhead box protein P1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114861:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:30411677-30803681

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021993

ENSBTAP00000021993

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002329	pre-B cell differentiation
GO:0002639	positive regulation of immunoglobulin production
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0030324	lung development
GO:0033152	immunoglobulin V(D)J recombination
GO:0045214	sarcomere organization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048745	smooth muscle tissue development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055007	cardiac muscle cell differentiation
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0061140	lung secretory cell differentiation
GO:0072358	cardiovascular system development
GO:1901249	regulation of lung goblet cell differentiation
GO:1901250	negative regulation of lung goblet cell differentiation
GO:2000727	positive regulation of cardiac muscle cell differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000114861

View Gene Order

ENSMUSG00000030067

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.17953

RefSeq

NM_001083689 XM_005222651 XM_005222652 XM_005222653 XM_005222654 XM_005222655 XM_005222656 XM_005222657 XM_005222658

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas