InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxp1

Summary

InnateDB Gene

IDBG-172640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxp1

Gene Name

forkhead box P1

Synonyms

3110052D19Rik; 4932443N09Rik; AI461938; AW494214

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030067

Encoded Proteins

IDBP-172642

forkhead box P1

IDBP-254106

forkhead box P1

IDBP-254108

forkhead box P1

IDBP-254110

forkhead box P1

IDBP-254112

forkhead box P1

IDBP-254114

forkhead box P1

IDBP-254116

forkhead box P1

IDBP-531573

forkhead box P1

IDBP-534523

forkhead box P1

IDBP-531935

forkhead box P1

IDBP-715254

IDBP-715177

IDBP-716142

IDBP-714791

IDBP-714828

IDBP-715968

IDBP-715670

IDBP-715196

IDBP-715561

IDBP-715135

IDBP-713952

IDBP-715376

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114861:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:98925338-99522721

Strand

Reverse strand

Band

Transcripts

ENSMUST00000074346	ENSMUSP00000073953
ENSMUST00000075832
ENSMUST00000113329	ENSMUSP00000108955
ENSMUST00000113328	ENSMUSP00000108954
ENSMUST00000113326	ENSMUSP00000108952
ENSMUST00000113324	ENSMUSP00000108950
ENSMUST00000113322	ENSMUSP00000108948
ENSMUST00000113321	ENSMUSP00000108947
ENSMUST00000124058	ENSMUSP00000120244
ENSMUST00000142164
ENSMUST00000154163	ENSMUSP00000121404
ENSMUST00000123992	ENSMUSP00000117550
ENSMUST00000138754
ENSMUST00000131967
ENSMUST00000175886	ENSMUSP00000135517
ENSMUST00000176565	ENSMUSP00000135181
ENSMUST00000177507	ENSMUSP00000134869
ENSMUST00000177227	ENSMUSP00000135229
ENSMUST00000175880
ENSMUST00000177235
ENSMUST00000175670	ENSMUSP00000135237
ENSMUST00000177307	ENSMUSP00000135764
ENSMUST00000176850	ENSMUSP00000135041
ENSMUST00000177229	ENSMUSP00000134817
ENSMUST00000175838
ENSMUST00000176148
ENSMUST00000177208	ENSMUSP00000135187
ENSMUST00000177410
ENSMUST00000177437	ENSMUSP00000135809
ENSMUST00000177230	ENSMUSP00000135098
ENSMUST00000176105
ENSMUST00000176632	ENSMUSP00000135635

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002329	pre-B cell differentiation
GO:0002639	positive regulation of immunoglobulin production
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0008045	motor neuron axon guidance
GO:0021517	ventral spinal cord development
GO:0030324	lung development
GO:0033152	immunoglobulin V(D)J recombination
GO:0045214	sarcomere organization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048745	smooth muscle tissue development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055007	cardiac muscle cell differentiation
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0061140	lung secretory cell differentiation
GO:0072358	cardiovascular system development
GO:1901249	regulation of lung goblet cell differentiation
GO:1901250	negative regulation of lung goblet cell differentiation
GO:2000727	positive regulation of cardiac muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114861

View Gene Order

ENSBTAG00000016533

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.234965 Mm.392884 Mm.400270 Mm.409291 Mm.436380 Mm.441772 Mm.485344

RefSeq

NM_001197321 NM_001197322 NM_053202 XM_006505308 XM_006505309 XM_006505310 XM_006505311 XM_006505312 XM_006505313 XM_006505314 XM_006505315 XM_006505316 XM_006505317 XM_006505319 XM_006505320 XM_006505321 XM_006505322 XM_006505323

OMIM

CCDS

CCDS39578 CCDS57441 CCDS57442

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas