Mus musculus Gene: Foxp1
Summary
InnateDB Gene IDBG-172640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxp1
Gene Name forkhead box P1
Synonyms 3110052D19Rik; 4932443N09Rik; AI461938; AW494214;
Species Mus musculus
Ensembl Gene ENSMUSG00000030067
Encoded Proteins
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
forkhead box P1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114861:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:98925338-99522721
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000074346 ENSMUSP00000073953
ENSMUST00000075832
ENSMUST00000113329 ENSMUSP00000108955
ENSMUST00000113328 ENSMUSP00000108954
ENSMUST00000113326 ENSMUSP00000108952
ENSMUST00000113324 ENSMUSP00000108950
ENSMUST00000113322 ENSMUSP00000108948
ENSMUST00000113321 ENSMUSP00000108947
ENSMUST00000124058 ENSMUSP00000120244
ENSMUST00000142164
ENSMUST00000154163 ENSMUSP00000121404
ENSMUST00000123992 ENSMUSP00000117550
ENSMUST00000138754
ENSMUST00000131967
ENSMUST00000175886 ENSMUSP00000135517
ENSMUST00000176565 ENSMUSP00000135181
ENSMUST00000177507 ENSMUSP00000134869
ENSMUST00000177227 ENSMUSP00000135229
ENSMUST00000175880
ENSMUST00000177235
ENSMUST00000175670 ENSMUSP00000135237
ENSMUST00000177307 ENSMUSP00000135764
ENSMUST00000176850 ENSMUSP00000135041
ENSMUST00000177229 ENSMUSP00000134817
ENSMUST00000175838
ENSMUST00000176148
ENSMUST00000177208 ENSMUSP00000135187
ENSMUST00000177410
ENSMUST00000177437 ENSMUSP00000135809
ENSMUST00000177230 ENSMUSP00000135098
ENSMUST00000176105
ENSMUST00000176632 ENSMUSP00000135635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 12 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002329 pre-B cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0008045 motor neuron axon guidance
GO:0021517 ventral spinal cord development
GO:0030324 lung development
GO:0033152 immunoglobulin V(D)J recombination
GO:0045214 sarcomere organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055007 cardiac muscle cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061140 lung secretory cell differentiation
GO:0072358 cardiovascular system development
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.234965 Mm.392884 Mm.400270 Mm.409291 Mm.436380 Mm.441772 Mm.485344
RefSeq NM_001197321 NM_001197322 NM_053202 XM_006505308 XM_006505309 XM_006505310 XM_006505311 XM_006505312 XM_006505313 XM_006505314 XM_006505315 XM_006505316 XM_006505317 XM_006505319 XM_006505320 XM_006505321 XM_006505322 XM_006505323
OMIM
CCDS CCDS39578 CCDS57441 CCDS57442
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas