Version 5.4
Bos taurus Gene: CTTN
Summary
InnateDB Gene IDBG-645078.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTTN
Gene Name src substrate cortactin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006071
Encoded Proteins
IDBP-697762
cortactin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085733:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:48167168-48194210
Strand Forward strand
Band
Transcripts
ENSBTAT00000007976 ENSBTAP00000007976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0070062 extracellular vesicular exosome
GO:1990023 mitotic spindle midzone
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085733
View Gene Order
ENSMUSG00000031078
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04530
Tight junction pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
mmu04530
Tight junction pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
syndecan_3_pathway
Syndecan-3-mediated signaling events
fgf_pathway
FGF signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL Q1RMR3
UniProt Splice Variant
Entrez Gene 506939
UniGene Bt.104985 Bt.47372
RefSeq NM_001075287 XM_005227317
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114761 DAAA02063676
GenPept AAI14762
RNA Seq Atlas 506939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca