Version 5.4
Bos taurus Gene: SLC9A1
Summary
InnateDB Gene IDBG-645084.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A1
Gene Name sodium/hydrogen exchanger 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008766
Encoded Proteins
IDBP-697763
sodium/hydrogen exchanger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090020:
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:126676550-126727482
Strand Forward strand
Band
Transcripts
ENSBTAT00000055788 ENSBTAP00000048292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015297 antiporter activity
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001101 response to acid
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0010447 response to acidity
GO:0035725 sodium ion transmembrane transport
GO:0051453 regulation of intracellular pH
GO:0055007 cardiac muscle cell differentiation
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000090020
View Gene Order
ENSMUSG00000028854
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19314
Sodium/Proton exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_120996
Hyaluronan uptake and degradation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_121083
Hyaluronan metabolism pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
REACT_222247
Glycosaminoglycan metabolism pathway
REACT_189085
Disease pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_211754
MPS IV - Morquio syndrome B pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_225132
MPS IV - Morquio syndrome A pathway
REACT_218935
MPS IIIC - Sanfilippo syndrome C pathway
REACT_188937
Metabolism pathway
REACT_224474
MPS I - Hurler syndrome pathway
REACT_227993
MPS IIID - Sanfilippo syndrome D pathway
REACT_269282
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_270278
Diseases of glycosylation pathway
REACT_268957
Defective CHSY1 causes TPBS pathway
REACT_268952
Defective B3GAT3 causes JDSSDHD pathway
REACT_215504
MPS II - Hunter syndrome pathway
REACT_269263
Diseases associated with glycosaminoglycan metabolism pathway
REACT_196551
Hyaluronan metabolism pathway
REACT_196554
Hyaluronan uptake and degradation pathway
REACT_219946
MPS IX - Natowicz syndrome pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_259261
Sodium/Proton exchangers pathway
REACT_203949
Glycogen storage diseases pathway
REACT_208416
MPS VII - Sly syndrome pathway
REACT_271176
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_269050
Defective CHST3 causes SEDCJD pathway
REACT_215179
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_268667
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_221180
MPS IIIB - Sanfilippo syndrome B pathway
REACT_221189
MPS IIIA - Sanfilippo syndrome A pathway
REACT_270086
Defective PAPSS2 causes SEMD-PA pathway
REACT_271374
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_217438
Mucopolysaccharidoses pathway
REACT_269577
Defective CHST6 causes MCDC1 pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
REACT_270174
Defective EXT2 causes exostoses 2 pathway
REACT_269276
Defective SLC26A2 causes chondrodysplasias pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04260
Cardiac muscle contraction pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04260
Cardiac muscle contraction pathway
mmu04971
Gastric acid secretion pathway
mmu04970
Salivary secretion pathway
mmu04976
Bile secretion pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
endothelinpathway
Endothelins
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL F1MHK2
UniProt Splice Variant
Entrez Gene 317654
UniGene Bt.528
RefSeq NM_174833
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006358
GenPept
RNA Seq Atlas 317654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca