Homo sapiens Gene: SLC9A1
InnateDB Gene IDBG-94809.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A1
Gene Name solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Synonyms APNH; NHE-1; NHE1; PPP1R143;
Species Homo sapiens
Ensembl Gene ENSG00000090020
Encoded Proteins
solute carrier family 9 (sodium/hydrogen exchanger), member 1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:27098815-27166981
Strand Reverse strand
Band p36.11
ENST00000263980 ENSP00000263980
ENST00000374086 ENSP00000363199
ENST00000374084 ENSP00000363197
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001101 response to acid
GO:0002026 regulation of the force of heart contraction
GO:0005975 carbohydrate metabolic process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0010447 response to acidity
GO:0014070 response to organic cyclic compound
GO:0016049 cell growth
GO:0030154 cell differentiation
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030214 hyaluronan catabolic process
GO:0030307 positive regulation of cell growth
GO:0032869 cellular response to insulin stimulus
GO:0035725 sodium ion transmembrane transport
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0045760 positive regulation of action potential
GO:0051259 protein oligomerization
GO:0051453 regulation of intracellular pH
GO:0051930 regulation of sensory perception of pain
GO:0055007 cardiac muscle cell differentiation
GO:0055085 transmembrane transport
GO:0070997 neuron death
GO:0071236 cellular response to antibiotic
GO:0071257 cellular response to electrical stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071436 sodium ion export
GO:0071456 cellular response to hypoxia
GO:0071468 cellular response to acidity
GO:0086003 cardiac muscle cell contraction
GO:1902533 positive regulation of intracellular signal transduction
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030315 T-tubule
GO:0042383 sarcolemma
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Transmembrane transport of small molecules pathway
Sodium/Proton exchangers pathway
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Hyaluronan uptake and degradation pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
Hyaluronan metabolism pathway
MPS IIIC - Sanfilippo syndrome C pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Cardiac muscle contraction pathway
Regulation of actin cytoskeleton pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Bile secretion pathway
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-beta
RhoA signaling pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.469116
RefSeq NM_003047
HPRD 00123
RNA Seq Atlas