InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APPL1

Summary

InnateDB Gene

IDBG-645314.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APPL1

Gene Name

DCC-interacting protein 13-alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006824

Encoded Proteins

IDBP-698020

DCC-interacting protein 13-alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157500:
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:44397100-44427704

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008971

ENSBTAP00000008971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043422	protein kinase B binding

Biological Process

GO:0008283	cell proliferation
GO:0046324	regulation of glucose import
GO:0090003	regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0016581	NuRD complex
GO:0070062	extracellular vesicular exosome