Bos taurus Gene: BT.20209
InnateDB Gene IDBG-645609.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20209
Gene Name ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms BAIAP3;
Species Bos taurus
Ensembl Gene ENSBTAG00000045817
Encoded Proteins
BRCA1 associated protein-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163930:
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq, Jul 2008]
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:49032830-49039996
Strand Forward strand
ENSBTAT00000064109 ENSBTAP00000054730
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0051726 regulation of cell cycle
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035517 PR-DUB complex
Homo sapiens
Mus musculus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
UniProt Splice Variant
Entrez Gene 100124510
UniGene Bt.20209
RefSeq NM_001102549
EMBL DAAA02054377 DAAA02054378
RNA Seq Atlas 100124510
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)