|Bos taurus Gene: BT.20209|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||ubiquitin carboxyl-terminal hydrolase BAP1|
BRCA1 associated protein-1
|Useful resources||Stemformatics EHFPI ImmGen|
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163930:
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq, Jul 2008]
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
|Genomic Location||Chromosome 22:49032830-49039996|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RNA Seq Atlas||100124510|
|Tag Count based mRNA-Abundances across 87 different Tissues (TPM).
Based on Data from Bovine Gene Atlas
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