Version 5.4
| Bos taurus Gene: CAMK2A | |||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||
| InnateDB Gene | IDBG-646280.3 | ||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
| Gene Symbol | CAMK2A | ||||||||||||||||||||||||||
| Gene Name | calcium/calmodulin-dependent protein kinase type II subunit alpha | ||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000020087 | ||||||||||||||||||||||||||
| Encoded Proteins |
calcium/calmodulin-dependent protein kinase type II subunit alpha
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| Protein Structure | |||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
| Summary |
[Homo sapiens] CAMK2A promotes TLR-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating MAP3K7 and IRF3 in macrophages. (Demonstrated in murine model)
[Mus musculus] Camk2a promotes Tlr-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating Map3k7 and Irf3 in mouse macrophages.
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| Entrez Gene | |||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070808:
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008] |
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| Gene Information | |||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:63576976-63641028 | ||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
TGF_beta_Receptor pathway
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| REACTOME |
Interferon gamma signaling pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Trafficking of AMPA receptors pathway
Cellular responses to stress pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Interferon Signaling pathway
Post NMDA receptor activation events pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Signaling by Wnt pathway
Cellular responses to stress pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Cytokine Signaling in Immune system pathway
beta-catenin independent WNT signaling pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Immune System pathway
Post NMDA receptor activation events pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Ca2+ pathway pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Signal Transduction pathway
Transmission across Chemical Synapses pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
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| KEGG |
GnRH signaling pathway pathway
Wnt signaling pathway pathway
Olfactory transduction pathway
ErbB signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Olfactory transduction pathway
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Wnt signaling pathway pathway
GnRH signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
Netrin-mediated signaling events
FGF signaling pathway
TGF-beta receptor signaling
Noncanonical Wnt signaling pathway
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| Cross-References | |||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||
| TrEMBL | Q08E45 | ||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||
| Entrez Gene | 530719 | ||||||||||||||||||||||||||
| UniGene | Bt.61581 | ||||||||||||||||||||||||||
| RefSeq | NM_001075938 | ||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||
| EMBL | BC123428 DAAA02020627 | ||||||||||||||||||||||||||
| GenPept | AAI23429 | ||||||||||||||||||||||||||
| RNA Seq Atlas | 530719 | ||||||||||||||||||||||||||