InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MCM2

Summary

InnateDB Gene

IDBG-646521.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014380

Encoded Proteins

IDBP-699340

minichromosome maintenance complex component 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073111:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:60565325-60581052

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019121

ENSBTAP00000019121

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity
GO:0042393	histone binding

Biological Process

GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006334	nucleosome assembly
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0042555	MCM complex