Bos taurus Gene: MCM2
Summary
InnateDB Gene IDBG-646521.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014380
Encoded Proteins
minichromosome maintenance complex component 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073111:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:60565325-60581052
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019121 ENSBTAP00000019121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Predicted by orthology
Total 76 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0042393 histone binding
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006334 nucleosome assembly
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0042555 MCM complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Unwinding of DNA pathway
Cell Cycle pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Unwinding of DNA pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
KEGG
DNA replication pathway
Cell cycle pathway
DNA replication pathway
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
ATR signaling pathway
Cross-References
SwissProt
TrEMBL F1N506
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:6944
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054693 DAAA02054694
GenPept
RNA Seq Atlas