Bos taurus Gene: GSTZ1
Summary
InnateDB Gene IDBG-646893.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTZ1
Gene Name maleylacetoacetate isomerase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002706
Encoded Proteins
maleylacetoacetate isomerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100577:
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:89596394-89604430
Strand Forward strand
Band
Transcripts
ENSBTAT00000003503 ENSBTAP00000003503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0016034 maleylacetoacetate isomerase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0009072 aromatic amino acid family metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Glutathione conjugation pathway
Phenylalanine and tyrosine catabolism pathway
Metabolism of amino acids and derivatives pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
Phase II conjugation pathway
Phenylalanine and tyrosine catabolism pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Glutathione conjugation pathway
Biological oxidations pathway
KEGG
Tyrosine metabolism pathway
Tyrosine metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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