Version 5.4
Bos taurus Gene: GSTZ1
Summary
InnateDB Gene IDBG-646893.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTZ1
Gene Name maleylacetoacetate isomerase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002706
Encoded Proteins
IDBP-699735
maleylacetoacetate isomerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100577:
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:89596394-89604430
Strand Forward strand
Band
Transcripts
ENSBTAT00000003503 ENSBTAP00000003503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0016034 maleylacetoacetate isomerase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0009072 aromatic amino acid family metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100577
View Gene Order
ENSMUSG00000021033
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1786
Phenylalanine and tyrosine catabolism pathway
REACT_6926
Glutathione conjugation pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_243247
Phase II conjugation pathway
REACT_261966
Phenylalanine and tyrosine catabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_215316
Glutathione conjugation pathway
REACT_232343
Biological oxidations pathway
KEGG
hsa00350
Tyrosine metabolism pathway
mmu00350
Tyrosine metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F6RQK3
UniProt Splice Variant
Entrez Gene 514822
UniGene
RefSeq
HUGO HGNC:4643
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02029721 DAAA02029722
GenPept
RNA Seq Atlas 514822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca