Mus musculus Gene: Gstz1
Summary
InnateDB Gene IDBG-159928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gstz1
Gene Name glutathione transferase zeta 1 (maleylacetoacetate isomerase)
Synonyms MAAI;
Species Mus musculus
Ensembl Gene ENSMUSG00000021033
Encoded Proteins
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100577:
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:87147707-87164721
Strand Forward strand
Band D2
Transcripts
ENSMUST00000063117 ENSMUSP00000053540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0016034 maleylacetoacetate isomerase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0006749 glutathione metabolic process
GO:0009072 aromatic amino acid family metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Phase II conjugation pathway
Phenylalanine and tyrosine catabolism pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Glutathione conjugation pathway
Biological oxidations pathway
KEGG
Tyrosine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Glutathione conjugation pathway
Phenylalanine and tyrosine catabolism pathway
Metabolism of amino acids and derivatives pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Tyrosine metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9WVL0
TrEMBL Q9JJA0
UniProt Splice Variant
Entrez Gene 14874
UniGene Mm.29652 Mm.400755
RefSeq NM_001252555 NM_001252556 NM_010363 XM_006515474 XM_006515475 XM_006515476
OMIM
CCDS CCDS26071
HPRD
IMGT
MGI ID MGI:1341859
MGI Symbol Gstz1
EMBL AB041613 AF093418 AK002398 AK075927 BC031777
GenPept AAD43846 AAH31777 BAA95096 BAB22070 BAC36059
RNA Seq Atlas 14874