Homo sapiens Gene: KLK1
Summary
InnateDB Gene IDBG-64886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK1
Gene Name kallikrein 1
Synonyms hK1; Klk6; KLKR;
Species Homo sapiens
Ensembl Gene ENSG00000167748
Encoded Proteins
kallikrein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
KLK1 is part of the kallikrein-kinin system (KKS) that is involved in cancer and angiogenesis.
KLK1 is involved in the enzymatic cascade known as the contact system in the blood which leads to an inflammatory response.
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50819148-50823787
Strand Reverse strand
Band q13.33
Transcripts
ENST00000301420 ENSP00000301420
ENST00000596300
ENST00000593325 ENSP00000472939
ENST00000593859
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Metabolism of proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P06870
TrEMBL F8WAM8 M0R318 Q9UE84
UniProt Splice Variant
Entrez Gene 3816
UniGene Hs.123107 Hs.738765
RefSeq NM_002257 XM_005258900
HUGO HGNC:6357
OMIM 147910
CCDS CCDS12804
HPRD
IMGT
EMBL AC010325 AF243527 AF277050 AY094609 AY703451 BC005313 BT007253 M12706 M25629 M33105 M33106 M33107 M33108 M33109 S77952 X13561
GenPept AAA36136 AAA59201 AAA59455 AAB34120 AAF86333 AAG33353 AAH05313 AAM11874 AAP35917 AAU12569 CAA31912
RNA Seq Atlas 3816