|Homo sapiens Gene: KLK1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||kallikrein 1|
|Synonyms||hK1; Klk6; KLKR;|
|Useful resources||Stemformatics EHFPI ImmGen|
KLK1 is part of the kallikrein-kinin system (KKS) that is involved in cancer and angiogenesis.
KLK1 is involved in the enzymatic cascade known as the contact system in the blood which leads to an inflammatory response.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 19:50819148-50823787|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Metabolism of proteins pathway
|TrEMBL||F8WAM8 M0R318 Q9UE84|
|UniProt Splice Variant|
|EMBL||AC010325 AF243527 AF277050 AY094609 AY703451 BC005313 BT007253 M12706 M25629 M33105 M33106 M33107 M33108 M33109 S77952 X13561|
|GenPept||AAA36136 AAA59201 AAA59455 AAB34120 AAF86333 AAG33353 AAH05313 AAM11874 AAP35917 AAU12569 CAA31912|
|RNA Seq Atlas||3816|