Homo sapiens Gene: KLK5
Summary
InnateDB Gene IDBG-65175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK5
Gene Name kallikrein-related peptidase 5
Synonyms KLK-L2; KLKL2; SCTE;
Species Homo sapiens
Ensembl Gene ENSG00000167754
Encoded Proteins
kallikrein-related peptidase 5
kallikrein-related peptidase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50943303-50953093
Strand Reverse strand
Band q13.41
Transcripts
ENST00000336334 ENSP00000337733
ENST00000391809 ENSP00000375685
ENST00000594846 ENSP00000469439
ENST00000595585
ENST00000593428 ENSP00000471966
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008544 epidermis development
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0097209 epidermal lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9Y337
TrEMBL A0A024R4G4 Q8IU55
UniProt Splice Variant
Entrez Gene 25818
UniGene Hs.50915
RefSeq NM_001077491 NM_012427 NM_001077492
HUGO HGNC:6366
OMIM 605643
CCDS CCDS12810
HPRD 05732
IMGT
EMBL AC011483 AF135028 AF168768 AF243527 AF435980 AF435981 AY279380 AY279381 AY359010 BC008036 BT006867 CH471135
GenPept AAD26429 AAF03101 AAG33358 AAH08036 AAN63606 AAN63607 AAP35513 AAP42275 AAP42276 AAQ89369 EAW71946 EAW71948 EAW71949 EAW71950 EAW71952
RNA Seq Atlas 25818