Version 5.4
Homo sapiens Gene: MELK
Summary
InnateDB Gene IDBG-65356.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MELK
Gene Name maternal embryonic leucine zipper kinase
Synonyms HPK38
Species Homo sapiens
Ensembl Gene ENSG00000165304
Encoded Proteins
IDBP-65358
maternal embryonic leucine zipper kinase
IDBP-588038
maternal embryonic leucine zipper kinase
IDBP-596496
maternal embryonic leucine zipper kinase
IDBP-584903
maternal embryonic leucine zipper kinase
IDBP-586300
maternal embryonic leucine zipper kinase
IDBP-585308
maternal embryonic leucine zipper kinase
IDBP-593761
maternal embryonic leucine zipper kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:36572862-36677683
Strand Forward strand
Band p13.2
Transcripts
ENST00000298048 ENSP00000298048
ENST00000489766
ENST00000495529
ENST00000487398
ENST00000480021
ENST00000545008 ENSP00000445452
ENST00000536860 ENSP00000439792
ENST00000541717 ENSP00000437804
ENST00000536329 ENSP00000443550
ENST00000543751 ENSP00000441596
ENST00000536987 ENSP00000439184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009103 lipopolysaccharide biosynthetic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030097 hemopoiesis
GO:0043065 positive regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035683
View Gene Order
ENSBTAG00000021686
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.184339
RefSeq NM_001256685 NM_001256687 NM_001256688 NM_001256689 NM_001256690 NM_001256691 NM_001256692 NM_001256693 NM_014791
HUGO
OMIM
CCDS CCDS59123 CCDS59124 CCDS59125 CCDS59126 CCDS59127 CCDS59128 CCDS6606
HPRD 06119
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca