Homo sapiens Gene: P2RX2
Summary
InnateDB Gene IDBG-65492.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX2
Gene Name purinergic receptor P2X, ligand-gated ion channel, 2
Synonyms DFNA41; P2X2;
Species Homo sapiens
Ensembl Gene ENSG00000187848
Encoded Proteins
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
purinergic receptor P2X, ligand-gated ion channel, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:132618780-132622386
Strand Forward strand
Band q24.33
Transcripts
ENST00000352418 ENSP00000341419
ENST00000351222 ENSP00000344502
ENST00000343948 ENSP00000343339
ENST00000389110 ENSP00000373762
ENST00000350048 ENSP00000343904
ENST00000348800 ENSP00000345095
ENST00000449132 ENSP00000405531
ENST00000542301 ENSP00000444477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0015276 ligand-gated ion channel activity
GO:0016151 nickel cation binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
GO:0045340 mercury ion binding
GO:0046870 cadmium ion binding
GO:0050897 cobalt ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007268 synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0007605 sensory perception of sound
GO:0009743 response to carbohydrate
GO:0010033 response to organic substance
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0014832 urinary bladder smooth muscle contraction
GO:0019228 neuronal action potential
GO:0030432 peristalsis
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0048266 behavioral response to pain
GO:0048741 skeletal muscle fiber development
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050909 sensory perception of taste
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005622 intracellular
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UBL9
TrEMBL
UniProt Splice Variant
Entrez Gene 22953
UniGene Hs.258580
RefSeq NM_174873 NM_001282164 NM_001282165 NM_012226 NM_016318 NM_170682 NM_170683 NM_174872
HUGO HGNC:15459
OMIM 600844
CCDS CCDS31932 CCDS31930 CCDS31931 CCDS31933 CCDS31934 CCDS31935 CCDS61286 CCDS73548
HPRD 15984
IMGT
EMBL AC131212 AF109387 AF109388 AF190822 AF190823 AF190824 AF190825 AF190826 AF260426 AF260427 AF260428 AF260429 AY346374
GenPept AAD42947 AAD42948 AAF19170 AAF19171 AAF19172 AAF19173 AAF19174 AAF74201 AAF74202 AAF74203 AAF74204 AAQ54329
RNA Seq Atlas 22953