Homo sapiens Gene: CCNB3
Summary
InnateDB Gene IDBG-67068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNB3
Gene Name cyclin B3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147082
Encoded Proteins
cyclin B3
cyclin B3
cyclin B3
cyclin B3
cyclin B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:50202713-50351910
Strand Forward strand
Band p11.22
Transcripts
ENST00000376042 ENSP00000365210
ENST00000376038 ENSP00000365206
ENST00000276014 ENSP00000276014
ENST00000348603 ENSP00000338682
ENST00000493507
ENST00000491907
ENST00000476167 ENSP00000431645
ENST00000487204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007126 meiotic nuclear division
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cell cycle pathway
p53 signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WWL7
TrEMBL Q8WTR6
UniProt Splice Variant
Entrez Gene 85417
UniGene Hs.130310 Hs.722420 Hs.722421 Hs.740165
RefSeq NM_033031 NM_033670 XM_006724610
HUGO HGNC:18709
OMIM 300456
CCDS CCDS14331 CCDS14332
HPRD 02350
IMGT
EMBL AJ314764 AJ314765 AJ314766 AJ416458 AJ421672 AJ421673 AJ421674 AL137550 AL591367 BX323840 CH471180
GenPept CAB70806 CAC40024 CAC40025 CAC40026 CAC94915 CAD18845 CAD18846 CAD18847 CAI41320 CAI41321 CAI43220 CAI43221 EAW89922 EAW89923
RNA Seq Atlas 85417