Version 5.4
Homo sapiens Gene: MBOAT7
Summary
InnateDB Gene IDBG-68251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBOAT7
Gene Name membrane bound O-acyltransferase domain containing 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125505
Encoded Proteins
IDBP-68253
membrane bound O-acyltransferase domain containing 7
IDBP-68255
membrane bound O-acyltransferase domain containing 7
IDBP-247055
membrane bound O-acyltransferase domain containing 7
IDBP-384616
membrane bound O-acyltransferase domain containing 7
IDBP-384618
membrane bound O-acyltransferase domain containing 7
IDBP-384620
membrane bound O-acyltransferase domain containing 7
IDBP-384623
membrane bound O-acyltransferase domain containing 7
IDBP-384628
membrane bound O-acyltransferase domain containing 7
IDBP-759894
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54173412-54189882
Strand Reverse strand
Band q13.42
Transcripts
ENST00000245615 ENSP00000245615
ENST00000338624 ENSP00000344377
ENST00000391754 ENSP00000375634
ENST00000437868 ENSP00000404915
ENST00000431666 ENSP00000410503
ENST00000449249 ENSP00000406794
ENST00000414665 ENSP00000388250
ENST00000453320 ENSP00000410320
ENST00000494142
ENST00000495279 ENSP00000472209
ENST00000464098
ENST00000474910
ENST00000491216
ENST00000495968
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0071617 lysophospholipid acyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0021591 ventricular system development
GO:0021819 layer formation in cerebral cortex
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046488 phosphatidylinositol metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035596
View Gene Order
ENSBTAG00000015908
Not yet available
Pathways
NETPATH
REACTOME
REACT_120722
Acyl chain remodelling of PI pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467279
RefSeq NM_001146056 NM_001146082 NM_001146083 NM_024298
HUGO
OMIM
CCDS CCDS12883 CCDS54315 CCDS54316
HPRD 06925
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca