Homo sapiens Gene: NCOA6
Summary
InnateDB Gene IDBG-68724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA6
Gene Name nuclear receptor coactivator 6
Synonyms AIB3; ASC2; NRC; PRIP; RAP250; TRBP;
Species Homo sapiens
Ensembl Gene ENSG00000198646
Encoded Proteins
nuclear receptor coactivator 6
nuclear receptor coactivator 6
nuclear receptor coactivator 6
nuclear receptor coactivator 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34696918-34825649
Strand Reverse strand
Band q11.22
Transcripts
ENST00000359003 ENSP00000351894
ENST00000374796 ENSP00000363929
ENST00000434040
ENST00000471897
ENST00000593786
ENST00000612493 ENSP00000481177
ENST00000616167 ENSP00000481935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 119 [view]
Protein-Protein 118 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0007507 heart development
GO:0009725 response to hormone
GO:0030099 myeloid cell differentiation
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0042921 glucocorticoid receptor signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060716 labyrinthine layer blood vessel development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0035097 histone methyltransferase complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Transmembrane transport of small molecules pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Circadian Clock pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
REV-ERBA represses gene expression pathway
Mitochondrial biogenesis pathway
PPARA activates gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Generic Transcription Pathway pathway
RORA activates circadian gene expression pathway
Orphan transporters pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Transcriptional activation of mitochondrial biogenesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368971 Hs.602604 Hs.606277
RefSeq NM_001242539 NM_014071 XM_005260348 XM_006723750 XM_006723753 XM_006723754 XM_006723755
HUGO
OMIM
CCDS CCDS13241 CCDS74720
HPRD 05599
IMGT
EMBL
GenPept
RNA Seq Atlas