InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACOX1

Summary

InnateDB Gene

IDBG-69159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOX1

Gene Name

acyl-CoA oxidase 1, palmitoyl

Synonyms

ACOX; PALMCOX; SCOX

Species

Homo sapiens

Ensembl Gene

ENSG00000161533

Encoded Proteins

IDBP-69161

acyl-CoA oxidase 1, palmitoyl

IDBP-69163

acyl-CoA oxidase 1, palmitoyl

IDBP-763344

IDBP-762235

IDBP-760212

IDBP-761367

IDBP-758285

IDBP-763001

IDBP-760482

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:75941507-75979363

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000293217	ENSP00000293217
ENST00000301608	ENSP00000301608
ENST00000591857
ENST00000572047	ENSP00000459936
ENST00000573078	ENSP00000458325
ENST00000589301	ENSP00000468435
ENST00000588968	ENSP00000468651
ENST00000588176	ENSP00000466210
ENST00000592329
ENST00000591963
ENST00000589744
ENST00000576743	ENSP00000461486
ENST00000587927	ENSP00000466921

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0005504	fatty acid binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006693	prostaglandin metabolic process
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0016559	peroxisome fission
GO:0019395	fatty acid oxidation
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055088	lipid homeostasis
GO:0055114	oxidation-reduction process
GO:2000189	positive regulation of cholesterol homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020777

View Gene Order

ENSBTAG00000030174

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00592

alpha-Linolenic acid metabolism pathway

hsa01040

Biosynthesis of unsaturated fatty acids pathway

hsa00071

Fatty acid degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.464137 Hs.597043 Hs.618977

RefSeq

NM_001185039 NM_004035 NM_007292

HUGO

OMIM

CCDS

CCDS11734 CCDS11735

HPRD

02030

IMGT

EMBL

GenPept

RNA Seq Atlas