Homo sapiens Gene: ACOX1
Summary
InnateDB Gene IDBG-69159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACOX1
Gene Name acyl-CoA oxidase 1, palmitoyl
Synonyms ACOX; PALMCOX; SCOX;
Species Homo sapiens
Ensembl Gene ENSG00000161533
Encoded Proteins
acyl-CoA oxidase 1, palmitoyl
acyl-CoA oxidase 1, palmitoyl
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75941507-75979363
Strand Reverse strand
Band q25.1
Transcripts
ENST00000293217 ENSP00000293217
ENST00000301608 ENSP00000301608
ENST00000591857
ENST00000572047 ENSP00000459936
ENST00000573078 ENSP00000458325
ENST00000589301 ENSP00000468435
ENST00000588968 ENSP00000468651
ENST00000588176 ENSP00000466210
ENST00000592329
ENST00000591963
ENST00000589744
ENST00000576743 ENSP00000461486
ENST00000587927 ENSP00000466921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0003997 acyl-CoA oxidase activity
GO:0005102 receptor binding
GO:0005504 fatty acid binding
GO:0016401 palmitoyl-CoA oxidase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0030165 PDZ domain binding
GO:0047485 protein N-terminus binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006693 prostaglandin metabolic process
GO:0007283 spermatogenesis
GO:0008152 metabolic process
GO:0016559 peroxisome fission
GO:0019395 fatty acid oxidation
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559 unsaturated fatty acid metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055088 lipid homeostasis
GO:0055114 oxidation-reduction process
GO:2000189 positive regulation of cholesterol homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Fatty acid degradation pathway
alpha-Linolenic acid metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
PPAR signaling pathway pathway
Peroxisome pathway
INOH
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
PID NCI
Cross-References
SwissProt Q15067
TrEMBL
UniProt Splice Variant
Entrez Gene 51
UniGene Hs.464137 Hs.597043 Hs.618977
RefSeq NM_007292 NM_004035 NM_001185039
HUGO HGNC:119
OMIM 609751
CCDS CCDS11735 CCDS11734
HPRD 02030
IMGT
EMBL AC040980 AC087289 AK291793 AK292965 AK296409 BC008767 BC010425 BX537380 CH471099 S69189 U03254 U03255 U03256 U03257 U03258 U03259 U03260 U03261 U03263 U03264 U03265 U03266 U03267 U03268 U07866 X71440
GenPept AAA18595 AAA19113 AAA19114 AAB30019 AAH08767 AAH10425 BAF84482 BAF85654 BAG59073 CAA50574 CAD97622 EAW89351
RNA Seq Atlas 51