Homo sapiens Gene: LGALS1
Summary
InnateDB Gene IDBG-6929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS1
Gene Name lectin, galactoside-binding, soluble, 1
Synonyms GAL1; GBP;
Species Homo sapiens
Ensembl Gene ENSG00000100097
Encoded Proteins
lectin, galactoside-binding, soluble, 1
lectin, galactoside-binding, soluble, 1
lectin, galactoside-binding, soluble, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LGALS1, the prototype of a family of beta-galactoside-binding proteins, is involved in monocyte chemoattraction at sites of inflammation where it stimulates monocyte migration in a dose-dependent manner via the p44/42 MAP kinase pathway.
LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.
Entrez Gene
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37675608-37679806
Strand Forward strand
Band q13.1
Transcripts
ENST00000215909 ENSP00000215909
ENST00000425542 ENSP00000404414
ENST00000454173 ENSP00000388296
ENST00000464120
ENST00000480207
ENST00000489315
ENST00000472321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
Experimentally validated
Total 59 [view]
Protein-Protein 57 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016936 galactoside binding
GO:0030246 carbohydrate binding
GO:0030395 lactose binding
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002317 plasma cell differentiation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0031295 T cell costimulation
GO:0033555 multicellular organismal response to stress
GO:0034120 positive regulation of erythrocyte aggregation
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045445 myoblast differentiation
GO:0048678 response to axon injury
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002305
HUGO
OMIM
CCDS CCDS13954
HPRD 01040
IMGT
EMBL
GenPept
RNA Seq Atlas