Homo sapiens Gene: SAP130
Summary
InnateDB Gene IDBG-69376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAP130
Gene Name Sin3A-associated protein, 130kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136715
Encoded Proteins
Sin3A-associated protein, 130kDa
Sin3A-associated protein, 130kDa
Sin3A-associated protein, 130kDa
Sin3A-associated protein, 130kDa
Sin3A-associated protein, 130kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127941217-128028120
Strand Reverse strand
Band q14.3
Transcripts
ENST00000357702 ENSP00000350333
ENST00000259235 ENSP00000259235
ENST00000259234 ENSP00000259234
ENST00000424298 ENSP00000411634
ENST00000450957 ENSP00000414593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005634 nucleus
GO:0030914 STAGA complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Epigenetic regulation of gene expression pathway
NoRC negatively regulates rRNA expression pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Gene Expression pathway
Negative epigenetic regulation of rRNA expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9JTJ5
UniProt Splice Variant
Entrez Gene 79595
UniGene Hs.32995
RefSeq NM_001145928 NM_024545 XM_005263769 XM_005263767 XM_006712748 XM_006712749 XM_005263770 XM_005263768
HUGO HGNC:29813
OMIM 609697
CCDS CCDS54397 CCDS2153
HPRD 18015
IMGT
EMBL AC012306 AC118060
GenPept
RNA Seq Atlas 79595