Homo sapiens Gene: CLDN1
Summary
InnateDB Gene IDBG-69639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN1
Gene Name claudin 1
Synonyms CLD1; ILVASC; SEMP1;
Species Homo sapiens
Ensembl Gene ENSG00000163347
Encoded Proteins
claudin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:190305701-190322475
Strand Reverse strand
Band q28
Transcripts
ENST00000295522 ENSP00000295522
ENST00000490800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0016032 viral process
GO:0016338 calcium-independent cell-cell adhesion
GO:0045216 cell-cell junction organization
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Pathogenic Escherichia coli infection pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Nectin adhesion pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.439060
RefSeq NM_021101
HUGO
OMIM
CCDS CCDS3295
HPRD 04760
IMGT
EMBL
GenPept
RNA Seq Atlas