InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLDN1

Summary

InnateDB Gene

IDBG-69639.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN1

Gene Name

claudin 1

Synonyms

CLD1; ILVASC; SEMP1

Species

Homo sapiens

Ensembl Gene

ENSG00000163347

Encoded Proteins

IDBP-69641

claudin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:190305701-190322475

Strand

Reverse strand

Band

q28

Transcripts

ENST00000295522	ENSP00000295522
ENST00000490800

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007155	cell adhesion
GO:0016032	viral process
GO:0016338	calcium-independent cell-cell adhesion
GO:0045216	cell-cell junction organization
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022512

View Gene Order

ENSBTAG00000013148

Not yet available

Pathways

NETPATH

REACTOME

REACT_19373

Tight junction interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

REACT_19331

Cell-cell junction organization pathway

KEGG

hsa05130

Pathogenic Escherichia coli infection pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa05160

Hepatitis C pathway

INOH

PID NCI

nectin_pathway

Nectin adhesion pathway

Cross-References

SwissProt

O95832

TrEMBL

A5JSJ9 B4DLC3

UniProt Splice Variant

Entrez Gene

9076

UniGene

Hs.439060

RefSeq

NM_021101

HUGO

HGNC:2032

OMIM

603718

CCDS

CCDS3295

HPRD

IMGT

EMBL

AF101051 AF115546 AF134160 AF260403 AF260404 AF260405 AF260406 AK296934 AK312866 AY358652 BC012471 CH471052 CR457138 EF564137

GenPept

AAD16433 AAD22962 AAF61393 AAH12471 AAK20945 AAQ89015 ABQ42705 BAG35718 BAG59485 CAG33419 EAW78107 EAW78108

RNA Seq Atlas

9076