InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNNI3

Summary

InnateDB Gene

IDBG-70218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNI3

Gene Name

troponin I type 3 (cardiac)

Synonyms

CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1

Species

Homo sapiens

Ensembl Gene

ENSG00000129991

Encoded Proteins

IDBP-70220

troponin I type 3 (cardiac)

IDBP-763516

IDBP-765008

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:55151767-55157773

Strand

Reverse strand

Band

q13.42

Transcripts

ENST00000344887	ENSP00000341838
ENST00000585806
ENST00000588882	ENSP00000466729
ENST00000590463
ENST00000586858	ENSP00000465258
ENST00000589864
ENST00000586669
ENST00000586446
ENST00000587176

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030172	troponin C binding
GO:0031014	troponin T binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0006941	striated muscle contraction
GO:0007507	heart development
GO:0030049	muscle filament sliding
GO:0032780	negative regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060047	heart contraction
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005861	troponin complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0043292	contractile fiber

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035458

View Gene Order

ENSBTAG00000006424

Not yet available

Pathways

NETPATH

REACTOME

REACT_16969

Striated Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

KEGG

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa04260

Cardiac muscle contraction pathway

hsa05414

Dilated cardiomyopathy pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000363

HUGO

OMIM

CCDS

CCDS42628

HPRD

11769

IMGT

EMBL

GenPept

RNA Seq Atlas