Homo sapiens Gene: CYTH1
Summary
InnateDB Gene IDBG-70852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYTH1
Gene Name cytohesin 1
Synonyms B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7;
Species Homo sapiens
Ensembl Gene ENSG00000108669
Encoded Proteins
cytohesin 1
cytohesin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq, Aug 2008]
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:78674048-78782297
Strand Reverse strand
Band q25.3
Transcripts
ENST00000361101 ENSP00000354398
ENST00000446868 ENSP00000389095
ENST00000589296 ENSP00000465252
ENST00000591095
ENST00000586175
ENST00000591574 ENSP00000465945
ENST00000591455 ENSP00000465665
ENST00000589297 ENSP00000466512
ENST00000586043 ENSP00000468433
ENST00000585509 ENSP00000465940
ENST00000587308 ENSP00000465530
ENST00000592497
ENST00000590775
ENST00000590300 ENSP00000466949
ENST00000586299
ENST00000586430
ENST00000589768 ENSP00000467052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0030155 regulation of cell adhesion
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL K7ENH6
UniProt Splice Variant
Entrez Gene 9267
UniGene Hs.191215 Hs.621782 Hs.627708 Hs.735291
RefSeq NM_004762 NM_001292019 NM_001292018 NM_017456 XM_006722182 XM_006722180 XM_006722181
HUGO HGNC:9501
OMIM 182115
CCDS CCDS42392 CCDS32754
HPRD 01630
IMGT
EMBL AC022966 AC099804
GenPept
RNA Seq Atlas 9267