Version 5.4
Homo sapiens Gene: RET
Summary
InnateDB Gene IDBG-71064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RET
Gene Name ret proto-oncogene
Synonyms CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51
Species Homo sapiens
Ensembl Gene ENSG00000165731
Encoded Proteins
IDBP-71066
ret proto-oncogene
IDBP-71068
ret proto-oncogene
IDBP-477249
ret proto-oncogene
IDBP-809123
ret proto-oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:43077027-43130351
Strand Forward strand
Band q11.21
Transcripts
ENST00000355710 ENSP00000347942
ENST00000340058 ENSP00000344798
ENST00000498820 ENSP00000419080
ENST00000479913
ENST00000615310 ENSP00000480088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 46 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0001657 ureteric bud development
GO:0001755 neural crest cell migration
GO:0001838 embryonic epithelial tube formation
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007156 homophilic cell adhesion
GO:0007158 neuron cell-cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0007497 posterior midgut development
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030155 regulation of cell adhesion
GO:0030182 neuron differentiation
GO:0030335 positive regulation of cell migration
GO:0033619 membrane protein proteolysis
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035799 ureter maturation
GO:0042493 response to drug
GO:0042551 neuron maturation
GO:0045793 positive regulation of cell size
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048265 response to pain
GO:0048484 enteric nervous system development
GO:0050770 regulation of axonogenesis
GO:0060041 retina development in camera-type eye
GO:0060384 innervation
GO:0061146 Peyer's patch morphogenesis
GO:0071300 cellular response to retinoic acid
GO:0072300 positive regulation of metanephric glomerulus development
GO:0097021 lymphocyte migration into lymphoid organs
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030110
View Gene Order
ENSBTAG00000000570
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05216
Thyroid cancer pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
ret_pathway
Signaling events regulated by Ret tyrosine kinase
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.350321 Hs.625268
RefSeq NM_020630 NM_020975 XM_006717936
HUGO
OMIM
CCDS CCDS53525 CCDS7200
HPRD 01266
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca