Version 5.4
Homo sapiens Gene: EPN1
Summary
InnateDB Gene IDBG-71084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPN1
Gene Name epsin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000063245
Encoded Proteins
IDBP-71086
epsin 1
IDBP-71088
epsin 1
IDBP-385468
epsin 1
IDBP-761602
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55675226-55709858
Strand Forward strand
Band q13.42
Transcripts
ENST00000270460 ENSP00000270460
ENST00000085079 ENSP00000085079
ENST00000411543 ENSP00000406209
ENST00000591743
ENST00000586194
ENST00000589704 ENSP00000466593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005543 phospholipid binding
GO:0008134 transcription factor binding
GO:0008289 lipid binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007565 female pregnancy
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048568 embryonic organ development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 coated pit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035203
View Gene Order
ENSBTAG00000046996
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
erbb1_internalization_pathway
Internalization of ErbB1
Cross-References
SwissProt Q9Y6I3
TrEMBL
UniProt Splice Variant
Entrez Gene 29924
UniGene Hs.279953
RefSeq NM_013333 XM_006723178 NM_001130071 NM_001130072 XM_005258829 XM_005258830
HUGO HGNC:21604
OMIM 607262
CCDS CCDS46200 CCDS46198 CCDS46199
HPRD 06270
IMGT
EMBL AC008735 AC010525 AF073727 AK022454 BC044651
GenPept AAD38326 AAH44651 BAB14041
RNA Seq Atlas 29924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca