Version 5.4
Homo sapiens Gene: SOCS4
Summary
InnateDB Gene IDBG-7209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS4
Gene Name suppressor of cytokine signaling 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000180008
Encoded Proteins
IDBP-7211
suppressor of cytokine signaling 4
IDBP-239484
suppressor of cytokine signaling 4
IDBP-585339
suppressor of cytokine signaling 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:55027230-55049488
Strand Forward strand
Band q22.3
Transcripts
ENST00000339298 ENSP00000341327
ENST00000395472 ENSP00000378855
ENST00000555846 ENSP00000452522
ENST00000553735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0016567 protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048379
View Gene Order
ENSBTAG00000021988
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04910
Insulin signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.532610 Hs.626411 Hs.735249
RefSeq NM_080867 NM_199421
HUGO
OMIM
CCDS CCDS9722
HPRD 18084
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca