Version 5.4
Homo sapiens Gene: REXO2
Summary
InnateDB Gene IDBG-72144.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REXO2
Gene Name REX2, RNA exonuclease 2 homolog (S. cerevisiae)
Synonyms REX2; RFN; SFN
Species Homo sapiens
Ensembl Gene ENSG00000076043
Encoded Proteins
IDBP-72146
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-587738
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-583876
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-592917
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-584378
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-595163
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-589514
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-583153
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-590617
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-600617
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-595730
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-597756
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-602969
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
IDBP-813798
RNA exonuclease 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
This gene encodes a 3\'-to-5\' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:114439386-114450279
Strand Forward strand
Band q23.2
Transcripts
ENST00000265881 ENSP00000265881
ENST00000544010
ENST00000544196 ENSP00000437460
ENST00000539754 ENSP00000440665
ENST00000539275 ENSP00000443842
ENST00000539333
ENST00000543243
ENST00000541703 ENSP00000442703
ENST00000543131 ENSP00000442380
ENST00000538198 ENSP00000441639
ENST00000539119 ENSP00000444421
ENST00000542186
ENST00000544827 ENSP00000441844
ENST00000546316 ENSP00000437380
ENST00000539788 ENSP00000446189
ENST00000538403 ENSP00000442162
ENST00000538791 ENSP00000441171
ENST00000540492
ENST00000544507
ENST00000611665 ENSP00000480535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009117 nucleotide metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032026
View Gene Order
ENSBTAG00000005843
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 25996
UniGene Hs.677190 Hs.740182
RefSeq NM_015523
HUGO HGNC:17851
OMIM 607149
CCDS CCDS8371
HPRD 06192
IMGT
EMBL
GenPept
RNA Seq Atlas 25996

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca