Version 5.4
Homo sapiens Gene: TRIM27
Summary
InnateDB Gene IDBG-72253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM27
Gene Name tripartite motif containing 27
Synonyms RFP; RNF76
Species Homo sapiens
Ensembl Gene ENSG00000204713
Encoded Proteins
IDBP-72255
tripartite motif containing 27
IDBP-72257
tripartite motif containing 27
IDBP-366905
tripartite motif containing 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23438823
TRIM27 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:28903002-28923989
Strand Reverse strand
Band p22.1
Transcripts
ENST00000377199 ENSP00000366404
ENST00000377194 ENSP00000366399
ENST00000414543 ENSP00000400058
ENST00000481474
ENST00000467742
ENST00000498117
ENST00000496091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 154 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 154 [view]
Protein-Protein 154 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002820 negative regulation of adaptive immune response
GO:0006351 transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032897 negative regulation of viral transcription
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0042147 retrograde transport, endosome to Golgi
GO:0045087 innate immune response (InnateDB)
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206 protein trimerization
GO:0070534 protein K63-linked ubiquitination
GO:0072643 interferon-gamma secretion
GO:0090281 negative regulation of calcium ion import
GO:1900041 negative regulation of interleukin-2 secretion
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016605 PML body
GO:0030904 retromer complex
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021326
View Gene Order
ENSBTAG00000000871
Not yet available
Cross-References
SwissProt P14373
TrEMBL Q9NZT8
UniProt Splice Variant
Entrez Gene 5987
UniGene Hs.440382 Hs.614196
RefSeq NM_006510
HUGO HGNC:9975
OMIM 602165
CCDS CCDS4654
HPRD 15996
IMGT
EMBL AF171101 AF230393 AF230394 AL662859 AL662871 BC013580 BC066924 BX000360 BX005144 BX119924 BX537153 CH471081 CR759942 J03407 Z84474 Z84476
GenPept AAA36564 AAF32265 AAG50172 AAG50173 AAH13580 AAH66924 CAB06480 CAI17553 CAI18381 CAI18618 CAI18619 CAI18645 CAI18646 CAI19959 CAM24901 CAM25659 CAM25871 CAM25872 CAM26230 CAM26231 CAQ07942 CAQ07943 EAX03176 EAX03177
RNA Seq Atlas 5987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca