Version 5.4
Homo sapiens Gene: MYL9
Summary
InnateDB Gene IDBG-72761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL9
Gene Name myosin, light chain 9, regulatory
Synonyms LC20; MLC-2C; MLC2; MRLC1; MYRL2
Species Homo sapiens
Ensembl Gene ENSG00000101335
Encoded Proteins
IDBP-72763
myosin, light chain 9, regulatory
IDBP-72765
myosin, light chain 9, regulatory
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:36541484-36551447
Strand Forward strand
Band q11.23
Transcripts
ENST00000279022 ENSP00000279022
ENST00000346786 ENSP00000217313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0007411 axon guidance
Cellular Component
GO:0001725 stress fiber
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0016460 myosin II complex
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067818
View Gene Order
ENSBTAG00000011473
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt P24844
TrEMBL
UniProt Splice Variant
Entrez Gene 10398
UniGene
RefSeq NM_006097 NM_181526
HUGO HGNC:15754
OMIM 609905
CCDS CCDS13276 CCDS13277
HPRD
IMGT
EMBL AF176043 AL050318 BC002648 CH471077 D82057 J02854
GenPept AAA59852 AAH02648 AAQ13654 BAB88917 CAB75369 CAC34440 EAW76129 EAW76131 EAW76132 EAW76133 EAW76134
RNA Seq Atlas 10398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca