Homo sapiens Gene: FXYD6
Summary
InnateDB Gene IDBG-73337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXYD6
Gene Name FXYD domain containing ion transport regulator 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137726
Encoded Proteins
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
FXYD domain containing ion transport regulator 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011] This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117820075-117877486
Strand Reverse strand
Band q23.3
Transcripts
ENST00000260282 ENSP00000260282
ENST00000527717 ENSP00000431446
ENST00000526014 ENSP00000433312
ENST00000524656 ENSP00000431427
ENST00000529335 ENSP00000436629
ENST00000524841 ENSP00000431913
ENST00000527429 ENSP00000464057
ENST00000530956 ENSP00000463158
ENST00000534125
ENST00000527053
ENST00000540359 ENSP00000444243
ENST00000539526 ENSP00000442756
ENST00000579486
ENST00000583233
ENST00000584230 ENSP00000464144
ENST00000584394 ENSP00000463160
ENST00000583660
ENST00000614497 ENSP00000482442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005216 ion channel activity
Biological Process
GO:0006811 ion transport
GO:0008150 biological_process
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001164831 NM_001164832 NM_001164836 NM_001164837 NM_001204268 NM_022003
HUGO
OMIM
CCDS CCDS73400 CCDS8387
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas