Homo sapiens Gene: A1CF
Summary
InnateDB Gene IDBG-74457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A1CF
Gene Name APOBEC1 complementation factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148584
Encoded Proteins
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:50799409-50885675
Strand Reverse strand
Band q11.23
Transcripts
ENST00000373995 ENSP00000363107
ENST00000373997 ENSP00000363109
ENST00000374001 ENSP00000363113
ENST00000373993 ENSP00000363105
ENST00000282641 ENSP00000282641
ENST00000395495 ENSP00000378873
ENST00000395489 ENSP00000378868
ENST00000414883 ENSP00000397953
ENST00000493415
ENST00000473480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0010467 gene expression
GO:0016554 cytidine to uridine editing
GO:0016556 mRNA modification
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0030895 apolipoprotein B mRNA editing enzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Editing: C to U Conversion pathway
Formation of the Editosome pathway
mRNA Editing pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NQ94
TrEMBL A0A024QZI9
UniProt Splice Variant
Entrez Gene 29974
UniGene Hs.282795
RefSeq NM_138933 NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 XM_005269718 XM_005269719 XM_005269720 XM_006717808 XM_006717809
HUGO HGNC:24086
OMIM
CCDS CCDS7243 CCDS7241 CCDS7242 CCDS73133
HPRD 10627
IMGT
EMBL AF209192 AF271789 AF271790 AJ272078 AJ272079 AK000324 AK291982 AL512366 AL589794 BC130519 BC144196 CH471083
GenPept AAF34824 AAF76221 AAF76222 AAI30520 AAI44197 BAA91086 BAF84671 CAB94754 CAB94755 CAI14233 CAI14235 CAI14236 CAI15762 CAI15763 CAI15764 EAW54133 EAW54134 EAW54135 EAW54137
RNA Seq Atlas 29974