Version 5.4
| Homo sapiens Gene: A1CF | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-74457.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | A1CF | ||||||||||||||||||
| Gene Name | APOBEC1 complementation factor | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000148584 | ||||||||||||||||||
| Encoded Proteins |
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
APOBEC1 complementation factor
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 10:50799409-50885675 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q11.23 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Formation of the Editosome pathway
mRNA Editing: C to U Conversion pathway
mRNA Editing pathway
Gene Expression pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9NQ94 | ||||||||||||||||||
| TrEMBL | A0A024QZM7 Q5T0W7 Q7Z2U9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 29974 | ||||||||||||||||||
| UniGene | Hs.282795 | ||||||||||||||||||
| RefSeq | NM_138932 XM_005269718 XM_005269719 XM_005269720 XM_006717808 NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138933 XM_006717809 | ||||||||||||||||||
| HUGO | HGNC:24086 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS7242 CCDS7241 CCDS7243 CCDS73133 | ||||||||||||||||||
| HPRD | 10627 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF209192 AF271789 AF271790 AJ272078 AJ272079 AK000324 AK291982 AL512366 AL589794 BC054873 BC130519 BC144196 CH471083 | ||||||||||||||||||
| GenPept | AAF34824 AAF76221 AAF76222 AAH54873 AAI30520 AAI44197 BAA91086 BAF84671 CAB94754 CAB94755 CAI14233 CAI14235 CAI14236 CAI15762 CAI15763 CAI15764 EAW54133 EAW54134 EAW54135 EAW54138 | ||||||||||||||||||
| RNA Seq Atlas | 29974 | ||||||||||||||||||