Homo sapiens Gene: ZWINT
Summary
InnateDB Gene IDBG-74819.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZWINT
Gene Name ZW10 interactor
Synonyms HZwint-1; KNTC2AP; ZWINT1;
Species Homo sapiens
Ensembl Gene ENSG00000122952
Encoded Proteins
ZW10 interactor
ZW10 interactor
ZW10 interactor
ZW10 interactor
ZW10 interacting kinetochore protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:56357228-56361275
Strand Reverse strand
Band q21.1
Transcripts
ENST00000373944 ENSP00000363055
ENST00000318387 ENSP00000322850
ENST00000361148 ENSP00000354921
ENST00000395405 ENSP00000378801
ENST00000494312
ENST00000460654
ENST00000478181
ENST00000489649 ENSP00000473330
ENST00000467523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000278 mitotic cell cycle
GO:0007049 cell cycle
GO:0007051 spindle organization
GO:0007093 mitotic cell cycle checkpoint
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051649 establishment of localization in cell
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591363 Hs.735076
RefSeq NM_001005413 NM_007057 NM_032997
HUGO
OMIM
CCDS CCDS31205 CCDS7249
HPRD 18366
IMGT
EMBL
GenPept
RNA Seq Atlas