InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZWINT

Summary

InnateDB Gene

IDBG-74819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZWINT

Gene Name

ZW10 interactor

Synonyms

HZwint-1; KNTC2AP; ZWINT1

Species

Homo sapiens

Ensembl Gene

ENSG00000122952

Encoded Proteins

IDBP-74821

ZW10 interactor

IDBP-74823

ZW10 interactor

IDBP-74827

ZW10 interactor

IDBP-239591

ZW10 interactor

IDBP-807029

ZW10 interacting kinetochore protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:56357228-56361275

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000373944	ENSP00000363055
ENST00000318387	ENSP00000322850
ENST00000361148	ENSP00000354921
ENST00000395405	ENSP00000378801
ENST00000494312
ENST00000460654
ENST00000478181
ENST00000489649	ENSP00000473330
ENST00000467523

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007093	mitotic cell cycle checkpoint
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051649	establishment of localization in cell

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle