Version 5.4
Homo sapiens Gene: SRPR
Summary
InnateDB Gene IDBG-75769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRPR
Gene Name signal recognition particle receptor (docking protein)
Synonyms DP; Sralpha
Species Homo sapiens
Ensembl Gene ENSG00000182934
Encoded Proteins
IDBP-75771
signal recognition particle receptor (docking protein)
IDBP-592911
signal recognition particle receptor (docking protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:126262919-126269144
Strand Reverse strand
Band q24.2
Transcripts
ENST00000332118 ENSP00000328023
ENST00000532259 ENSP00000435508
ENST00000532268
ENST00000531104
ENST00000527817
ENST00000528744
ENST00000530680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 11 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005047 signal recognition particle binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0010467 gene expression
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005785 signal recognition particle receptor complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032042
View Gene Order
ENSBTAG00000014105
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa03060
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368376 Hs.718742
RefSeq NM_001177842 NM_003139
HUGO
OMIM
CCDS CCDS31717 CCDS53722
HPRD 01645
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca