Homo sapiens Gene: SUN2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-7758.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SUN2 | ||||||||||||||||||||||
Gene Name | Sad1 and UNC84 domain containing 2 | ||||||||||||||||||||||
Synonyms | UNC84B | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000100242 | ||||||||||||||||||||||
Encoded Proteins |
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
Sad1 and UNC84 domain containing 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a \'bridge\' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 22:38734725-38794143 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q13.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Meiotic synapsis pathway
Cell Cycle pathway
Meiosis pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | B0QY66 B0QY68 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 25777 | ||||||||||||||||||||||
UniGene | Hs.517622 Hs.740137 | ||||||||||||||||||||||
RefSeq | NM_001199579 NM_001199580 NM_015374 XM_005261500 XM_005261501 | ||||||||||||||||||||||
HUGO | HGNC:14210 | ||||||||||||||||||||||
OMIM | 613569 | ||||||||||||||||||||||
CCDS | CCDS13978 CCDS56231 | ||||||||||||||||||||||
HPRD | 15611 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL008583 AL021707 AL021806 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 25777 | ||||||||||||||||||||||