Homo sapiens Gene: SATB2
Summary
InnateDB Gene IDBG-78104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SATB2
Gene Name SATB homeobox 2
Synonyms GLSS;
Species Homo sapiens
Ensembl Gene ENSG00000119042
Encoded Proteins
SATB homeobox 2
SATB homeobox 2
SATB homeobox 2
SATB homeobox 2
SATB homeobox 2
SATB homeobox 2
SATB homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:199269500-199471266
Strand Reverse strand
Band q33.1
Transcripts
ENST00000260926 ENSP00000260926
ENST00000417098 ENSP00000401112
ENST00000443023 ENSP00000388764
ENST00000428695 ENSP00000388581
ENST00000457245 ENSP00000405420
ENST00000440919 ENSP00000415610
ENST00000473517
ENST00000483346
ENST00000484124
ENST00000463386
ENST00000614512 ENSP00000483287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 7 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001764 neuron migration
GO:0002076 osteoblast development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009880 embryonic pattern specification
GO:0010468 regulation of gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048704 embryonic skeletal system morphogenesis
GO:0051216 cartilage development
GO:0060021 palate development
GO:0071310 cellular response to organic substance
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516617
RefSeq NM_001172509 NM_001172517 NM_015265 XM_006712372
HUGO
OMIM
CCDS CCDS2327
HPRD 12178
IMGT
EMBL
GenPept
RNA Seq Atlas