Version 5.4
Homo sapiens Gene: ACOT8
Summary
InnateDB Gene IDBG-78312.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACOT8
Gene Name acyl-CoA thioesterase 8
Synonyms hACTE-III; HNAACTE; hTE; PTE-1; PTE-2; PTE1; PTE2
Species Homo sapiens
Ensembl Gene ENSG00000101473
Encoded Proteins
IDBP-78314
acyl-CoA thioesterase 8
IDBP-376670
acyl-CoA thioesterase 8
IDBP-376671
acyl-CoA thioesterase 8
IDBP-587193
acyl-CoA thioesterase 8
IDBP-587210
acyl-CoA thioesterase 8
IDBP-477886
acyl-CoA thioesterase 8
IDBP-599174
acyl-CoA thioesterase 8
IDBP-602154
acyl-CoA thioesterase 8
IDBP-597829
acyl-CoA thioesterase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45841721-45857406
Strand Reverse strand
Band q13.12
Transcripts
ENST00000217455 ENSP00000217455
ENST00000457981 ENSP00000403862
ENST00000426915 ENSP00000416217
ENST00000461272 ENSP00000435581
ENST00000488679 ENSP00000435115
ENST00000487205 ENSP00000419403
ENST00000493118
ENST00000484975
ENST00000483141 ENSP00000434216
ENST00000484783
ENST00000486165 ENSP00000433923
ENST00000481938 ENSP00000431175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0033882 choloyl-CoA hydrolase activity
GO:0047617 acyl-CoA hydrolase activity
GO:0052815 medium-chain acyl-CoA hydrolase activity
Biological Process
GO:0006637 acyl-CoA metabolic process
GO:0006699 bile acid biosynthetic process
GO:0008206 bile acid metabolic process
GO:0016032 viral process
GO:0016559 peroxisome fission
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559 unsaturated fatty acid metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0043649 dicarboxylic acid catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017307
View Gene Order
ENSBTAG00000020371
Not yet available
Pathways
NETPATH
REACTOME
REACT_17062
Beta-oxidation of very long chain fatty acids pathway
REACT_17017
Beta-oxidation of pristanoyl-CoA pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_121147
alpha-linolenic acid (ALA) metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_121284
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00120
Primary bile acid biosynthesis pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444776 Hs.634491 Hs.731462
RefSeq NM_005469 XM_005260239
HUGO
OMIM
CCDS CCDS13378
HPRD 06998
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca