Version 5.4
Homo sapiens Gene: APOM
Summary
InnateDB Gene IDBG-78460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOM
Gene Name apolipoprotein M
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204444
Encoded Proteins
IDBP-78462
apolipoprotein M
IDBP-78464
apolipoprotein M
IDBP-78466
apolipoprotein M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31652416-31658210
Strand Forward strand
Band p21.33
Transcripts
ENST00000375920 ENSP00000365085
ENST00000375918 ENSP00000365083
ENST00000375916 ENSP00000365081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005543 phospholipid binding
GO:0016209 antioxidant activity
Biological Process
GO:0009749 response to glucose
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034384 high-density lipoprotein particle clearance
GO:0034445 negative regulation of plasma lipoprotein particle oxidation
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024391
View Gene Order
ENSBTAG00000008833
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001256169 NM_019101 XM_006715150 XM_006725493 XM_006725707 XM_006725824 XM_006725916 XM_006726009 XM_006726104
HUGO
OMIM
CCDS CCDS4710 CCDS59004
HPRD 06068
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca