Homo sapiens Gene: ABCA1
Summary
InnateDB Gene IDBG-79441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCA1
Gene Name ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms ABC-1; ABC1; CERP; HDLDT1; TGD;
Species Homo sapiens
Ensembl Gene ENSG00000165029
Encoded Proteins
ATP-binding cassette, sub-family A (ABC1), member 1
ATP-binding cassette, sub-family A (ABC1), member 1
ATP-binding cassette, sub-family A (ABC1), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ABCA1 promotes the efflux of bacterial lipopolysaccharide (LPS) from macrophages and accelerates recovery from LPS-induced tolerance.
ABCA1 in macrophages dampens inflammation by reducing MYD88-dependent TLR trafficking to lipid rafts, thus selectively reducing free cholesterol content in lipid rafts.
ABCA1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Abca1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes.
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier\'s disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:104781002-104928237
Strand Reverse strand
Band q31.1
Transcripts
ENST00000374736 ENSP00000363868
ENST00000374733 ENSP00000363865
ENST00000423487 ENSP00000416623
ENST00000494467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 42 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005548 phospholipid transporter activity
GO:0008509 anion transmembrane transporter activity
GO:0015485 cholesterol binding
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0019905 syntaxin binding
GO:0031267 small GTPase binding
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034188 apolipoprotein A-I receptor activity
GO:0051117 ATPase binding
Biological Process
GO:0002790 peptide secretion
GO:0006200 ATP catabolic process
GO:0006497 protein lipidation
GO:0006911 phagocytosis, engulfment
GO:0007040 lysosome organization
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0015914 phospholipid transport
GO:0016197 endosomal transport
GO:0030301 cholesterol transport
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032367 intracellular cholesterol transport
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034380 high-density lipoprotein particle assembly
GO:0034616 response to laminar fluid shear stress
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045332 phospholipid translocation
GO:0050702 interleukin-1 beta secretion
GO:0055091 phospholipid homeostasis
GO:0055098 response to low-density lipoprotein particle stimulus
GO:0060155 platelet dense granule organization
GO:0071222 cellular response to lipopolysaccharide
GO:0071300 cellular response to retinoic acid
GO:0071397 cellular response to cholesterol
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030139 endocytic vesicle
GO:0034364 high-density lipoprotein particle
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
HDL-mediated lipid transport pathway
Lipoprotein metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
ABC transporters pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
RXR and RAR heterodimerization with other nuclear receptor
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.659274
RefSeq NM_005502
HUGO
OMIM
CCDS CCDS6762
HPRD 02501
IMGT
EMBL
GenPept
RNA Seq Atlas