Homo sapiens Gene: NCOA3
Summary
InnateDB Gene IDBG-79741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA3
Gene Name nuclear receptor coactivator 3
Synonyms ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26; KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1;
Species Homo sapiens
Ensembl Gene ENSG00000124151
Encoded Proteins
nuclear receptor coactivator 3
nuclear receptor coactivator 3
nuclear receptor coactivator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:47501902-47656877
Strand Forward strand
Band q13.12
Transcripts
ENST00000372004 ENSP00000361073
ENST00000371998 ENSP00000361066
ENST00000371997 ENSP00000361065
ENST00000490248
ENST00000497292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 174 [view]
Protein-Protein 154 [view]
Protein-DNA 9 [view]
Protein-RNA 1 [view]
DNA-DNA 10 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257 nuclear hormone receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0046983 protein dimerization activity
GO:0047485 protein N-terminus binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0010628 positive regulation of gene expression
GO:0016573 histone acetylation
GO:0030521 androgen receptor signaling pathway
GO:0035264 multicellular organism growth
GO:0035624 receptor transactivation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048589 developmental growth
GO:0060068 vagina development
GO:0060713 labyrinthine layer morphogenesis
GO:0060744 mammary gland branching involved in thelarche
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
IL4 pathway
TSLP pathway
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
INOH
PID BIOCARTA
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Biocarta view]
Control of gene expression by vitamin d receptor [Biocarta view]
Transcription regulation by methyltransferase of carm1 [Biocarta view]
PID NCI
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Retinoic acid receptors-mediated signaling
FOXA1 transcription factor network
Cross-References
SwissProt Q9Y6Q9
TrEMBL B4DYT5 Q569F6
UniProt Splice Variant
Entrez Gene 8202
UniGene Hs.592142 Hs.601833 Hs.613140 Hs.696465
RefSeq NM_001174087 NM_181659 NM_006534 NM_001174088
HUGO HGNC:7670
OMIM 601937
CCDS CCDS13407 CCDS13406 CCDS54472
HPRD 03570
IMGT
EMBL AF010227 AF012108 AF016031 AF036892 AK302595 AL034418 BC092516 BC119001 CH471077 EF488684
GenPept AAB92368 AAC51663 AAC51677 AAC51849 AAH92516 AAI19002 ABO43042 BAG63847 CAB40662 CAC17693 CAI42141 EAW75698 EAW75702
RNA Seq Atlas 8202