Homo sapiens Gene: TBC1D8B
Summary
InnateDB Gene IDBG-81238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D8B
Gene Name TBC1 domain family, member 8B (with GRAM domain)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133138
Encoded Proteins
TBC1 domain family, member 8B (with GRAM domain)
TBC1 domain family, member 8B (with GRAM domain)
TBC1 domain family, member 8B (with GRAM domain)
TBC1 domain family, member 8B (with GRAM domain)
TBC1 domain family, member 8B (with GRAM domain)
TBC1 domain family, member 8B (with GRAM domain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a TBC (Tre-2/Bub2/CDC16) domain. Some mammalian proteins with this domain have been shown to function as Rab-GAPs by binding to specific Rab proteins and affecting their GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:106802680-106876145
Strand Forward strand
Band q22.3
Transcripts
ENST00000357242 ENSP00000349781
ENST00000276175 ENSP00000276175
ENST00000310452 ENSP00000310675
ENST00000431860 ENSP00000396440
ENST00000481617 ENSP00000421375
ENST00000460545 ENSP00000422353
ENST00000492970
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005509 calcium ion binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q0IIM8
TrEMBL D6RC82
UniProt Splice Variant
Entrez Gene 54885
UniGene Hs.351798 Hs.600760
RefSeq NM_198881 NM_017752 XM_006724670
HUGO HGNC:24715
OMIM
CCDS CCDS14523 CCDS14522
HPRD 06529
IMGT
EMBL AB449890 AB449891 AK000305 AK123957 AL391315 AL591849 BC122564
GenPept AAI22565 BAA91071 BAC85735 BAH16633 BAH16634 CAI39548 CAI40161
RNA Seq Atlas 54885