Homo sapiens Gene: MINPP1
Summary
InnateDB Gene IDBG-81289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MINPP1
Gene Name multiple inositol-polyphosphate phosphatase 1
Synonyms HIPER1; MINPP2; MIPP;
Species Homo sapiens
Ensembl Gene ENSG00000107789
Encoded Proteins
multiple inositol-polyphosphate phosphatase 1
multiple inositol-polyphosphate phosphatase 1
multiple inositol-polyphosphate phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:87504875-87553460
Strand Forward strand
Band q23.2
Transcripts
ENST00000371996 ENSP00000361064
ENST00000371994 ENSP00000361062
ENST00000472891
ENST00000536010 ENSP00000437823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
GO:0008969 phosphohistidine phosphatase activity
GO:0016791 phosphatase activity
GO:0034417 bisphosphoglycerate 3-phosphatase activity
GO:0052826 inositol hexakisphosphate 2-phosphatase activity
Biological Process
GO:0001503 ossification
GO:0006797 polyphosphate metabolic process
GO:0016311 dephosphorylation
GO:0030282 bone mineralization
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis of IPs in the ER lumen pathway
Inositol phosphate metabolism pathway
Metabolism pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Inositol phosphate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.121260
RefSeq NM_001178117 NM_001178118 NM_004897
HUGO
OMIM
CCDS CCDS53551 CCDS53552 CCDS7384
HPRD 05652
IMGT
EMBL
GenPept
RNA Seq Atlas