Homo sapiens Gene: HLA-DMA
Summary
InnateDB Gene IDBG-81652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DMA
Gene Name major histocompatibility complex, class II, DM alpha
Synonyms D6S222E; DMA; HLADM; RING6;
Species Homo sapiens
Ensembl Gene ENSG00000204257
Encoded Proteins
major histocompatibility complex, class II, DM alpha
major histocompatibility complex, class II, DM alpha
major histocompatibility complex, class II, DM alpha
major histocompatibility complex, class II, DM alpha
major histocompatibility complex, class II, DM alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32948613-32969094
Strand Reverse strand
Band p21.32
Transcripts
ENST00000374843 ENSP00000363976
ENST00000395305 ENSP00000378716
ENST00000395303 ENSP00000378714
ENST00000456800 ENSP00000409668
ENST00000422832 ENSP00000403122
ENST00000477541
ENST00000480785
ENST00000464392
ENST00000475627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002503 peptide antigen assembly with MHC class II protein complex
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006461 protein complex assembly
GO:0006955 immune response
GO:0015031 protein transport
GO:0016064 immunoglobulin mediated immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045059 positive thymic T cell selection
GO:0045582 positive regulation of T cell differentiation
GO:0048839 inner ear development
GO:0050778 positive regulation of immune response
GO:0051085 chaperone mediated protein folding requiring cofactor
Cellular Component
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0042612 MHC class I protein complex
GO:0042613 MHC class II protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F6S093 H0Y732
UniProt Splice Variant
Entrez Gene 3108
UniGene Hs.717533
RefSeq NM_006120
HUGO HGNC:4934
OMIM 142855
CCDS CCDS4761
HPRD 00830
IMGT
EMBL AL645941
GenPept
RNA Seq Atlas 3108