Homo sapiens Gene: SPO11
Summary
InnateDB Gene IDBG-82085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPO11
Gene Name SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
Synonyms CT35; SPATA43; TOPVIA;
Species Homo sapiens
Ensembl Gene ENSG00000054796
Encoded Proteins
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5\' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:57329759-57343994
Strand Forward strand
Band q13.31
Transcripts
ENST00000371263 ENSP00000360310
ENST00000345868 ENSP00000316034
ENST00000371260 ENSP00000360307
ENST00000418127 ENSP00000413185
ENST00000494972 ENSP00000431842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001541 ovarian follicle development
GO:0006259 DNA metabolic process
GO:0007129 synapsis
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007292 female gamete generation
GO:0034502 protein localization to chromosome
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle pathway
Meiotic recombination pathway
Meiosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.159737
RefSeq NM_012444 NM_198265 XM_005260381
HUGO
OMIM
CCDS CCDS13456 CCDS13457
HPRD 09236
IMGT
EMBL
GenPept
RNA Seq Atlas