Version 5.4
Homo sapiens Gene: RXRB
Summary
InnateDB Gene IDBG-82238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RXRB
Gene Name retinoid X receptor, beta
Synonyms DAUDI6; H-2RIIBP; NR2B2; RCoR-1
Species Homo sapiens
Ensembl Gene ENSG00000204231
Encoded Proteins
IDBP-82240
retinoid X receptor, beta
IDBP-82246
retinoid X receptor, beta
IDBP-599621
retinoid X receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33193588-33200688
Strand Reverse strand
Band p21.32
Transcripts
ENST00000374685 ENSP00000363817
ENST00000374680 ENSP00000363812
ENST00000483281 ENSP00000431369
ENST00000483821
ENST00000481441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 32 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004886 9-cis retinoic acid receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001893 maternal placenta development
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048384 retinoic acid receptor signaling pathway
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039656
View Gene Order
ENSBTAG00000000602
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05216
Thyroid cancer pathway
hsa05222
Small cell lung cancer pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt P28702
TrEMBL E9PK75
UniProt Splice Variant
Entrez Gene 6257
UniGene Hs.388034
RefSeq NM_001270401 NM_001291989 XM_006715162 XM_006725708 NM_021976 XM_005249279 XM_005275008
HUGO HGNC:10478
OMIM 180246
CCDS CCDS59007 CCDS4768
HPRD 01578
IMGT
EMBL AB209244 AF065396 AF120161 AL031228 AL645940 AL662824 AL844527 BC001167 CR354565 CR759733 CR936877 HQ709179 M84820 X63522 X66424
GenPept AAA60293 AAC18599 AAD13794 AAH01167 ADZ17386 BAD92481 CAA20239 CAA45087 CAI41836 CAQ09065 CAQ10299 CAQ11083
RNA Seq Atlas 6257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca